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Article

Screening for therapeutic targets of vorinostat by SILAC‐based proteomic analysis in human breast cancer cells

4 Jan 2010

Abstract excerpt

Histone deacetylases (HDACs) play critical roles in silencing tumor suppressor genes. HDAC inhibitors reactivate tumor suppressor genes and inhibit tumor cell growth in vitro and in vivo, and several HDAC inhibitors are currently being evaluated in clinical trials for cancer therapy. A comprehensive analysis of proteins regulated by HDAC inhibitors would enhance our ability to define and characterize their...

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PMID: 20049865
DOI: 10.1002/pmic.200900602

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