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Quantitative Mass Spectrometry Reveals that Intact Histone H1 Phosphorylations are Variant Specific and Exhibit Single Molecule Hierarchical Dependence.

Molecular & cellular proteomics : MCP - 1 Mar 2016

Chen Yu, Hoover Michael E, Dang Xibei, Shomo Alan A, Guan Xiaoyan, Marshall Alan G, Freitas Michael A, Young Nicolas L

Abstract excerpt

Breast cancer was the second leading cause of cancer related mortality for females in 2014. Recent studies suggest histone H1 phosphorylation may be useful as a clinical biomarker of breast and other cancers because of its ability to recognize proliferative cell populations. Although monitoring a single phosphorylated H1 residue is adequate to stratify high-grade breast tumors, expanding our knowledge of how H1...

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Identifiers

PMID: 26209608
DOI: 10.1074/mcp.M114.046441
PMCID: PMC4813703

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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