Article
Prediction of BRCA2-association in hereditary breast carcinomas using array-CGH.
Breast cancer research and treatment - 1 Apr 2012
Joosse Simon A, Brandwijk Kim I M, Devilee Peter, Wesseling Jelle, Hogervorst Frans B L, Verhoef Senno, Nederlof Petra M
Abstract excerpt
Germline mutations in BRCA1/2 increase the lifetime risk for breast and ovarian cancer dramatically. Identification of such mutations is important for optimal treatment decisions and pre-symptomatic mutation screening in family members. Although current DNA diagnostics is able to identify many different mutations, it remains unclear, how many BRCA2-associated breast cancer cases remain unidentified as such. In...
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