Article
Genetic profiles distinguish different types of hereditary ovarian cancer.
Oncology reports - 1 Oct 2010
Domanska Katarina, Malander Susanne, Staaf Johan, Karlsson Anna, Borg Ake, Jönsson Göran, Nilbert Mef
Abstract excerpt
Heredity represents the strongest risk factor for ovarian cancer with disease predisposing mutations identified in 15% of the tumors. With the aim to identify genetic classifiers for hereditary ovarian cancer, we profiled hereditary ovarian cancers linked to the hereditary breast and ovarian cancer (HBOC) syndrome and the hereditary non-polyposis colorectal cancer (HNPCC) syndrome. Genome-wide array comparative...
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