Article
The molecular pathology of hereditary breast cancer: genetic testing and therapeutic implications.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Oct 2005
Honrado Emiliano, Benítez Javier, Palacios José
Abstract excerpt
Cancer arising in carriers of mutations in the BRCA1 and BRCA2 genes differs from sporadic breast cancer of age-matched controls and from non-BRCA1/2 familial breast carcinomas in its morphological, immunophenotypic and molecular characteristics. Most BRCA1 carcinomas have the basal cell phenotype, a subtype of high-grade, highly proliferating, estrogen receptor- and HER2-negative breast carcinomas, characterized...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.