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An immune-centric exploration of BRCA1 and BRCA2 germline mutation related breast and ovarian cancers

12 Mar 2020

Abstract excerpt

BACKGROUND: BRCA1/2 germline mutation related cancers are candidates for new immune therapeutic interventions. This study was a hypothesis generating exploration of genomic data collected at diagnosis for 19 patients. The prominent tumor mutation burden (TMB) in hereditary breast and ovarian cancers in this cohort was not correlated with high global immune activity in their microenvironments. More information is...

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PMID: 32164626
DOI: 10.1186/s12885-020-6605-1

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