Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic characterization of BRCA1 and BRCA2 tumors based in a tissue microarray study with 37 immunohistochemical markers.

Breast cancer research and treatment - 1 Mar 2005

Palacios José, Honrado Emiliano, Osorio Ana, Cazorla Alicia, Sarrió David, Barroso Alicia, Rodríguez Sandra, Cigudosa Juan C, Diez Orland, Alonso Carmen, Lerma Enrique, Dopazo Joaquín, Rivas Carmen, Benítez Javier

Abstract excerpt

Familial breast cancers that are associated with BRCA1 or BRCA2 germline mutations differ in both their morphological and immunohistochemical characteristics. To further characterize the molecular difference between genotypes, the authors evaluated the expression of 37 immunohistochemical markers in a tissue microarray (TMA) containing cores from 20 BRCA1, 14 BRCA2, and 59 sporadic age-matched breast carcinomas....

Topics

Adult
Apoptosis
Biomarkers, Tumor
Breast Neoplasms
Cell Cycle Proteins
Cluster Analysis
Female
Genes, BRCA1
Genes, BRCA2
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunohistochemistry

In Situ Hybridization, Fluorescence

Phenotype

Spain

Tissue Array Analysis

Source

Identifiers

PMID: 15770521
DOI: 10.1007/s10549-004-1536-0

Genes

BRCA1
BRCA2
BCL2
CCND1
CDK1
CDK2
CDK4
MYC
SKP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15770521-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic characterization of BRCA1 and BRCA2 tumors based in a tissue microarray study with 37 immunohistochemical markers.PMID 15770521Read ↗

Phenotypic characterization of hereditary epithelial ovarian cancer based on a tissue microarray study.Semantic proximity Read ↗

Immunohistochemical characteristics defined by tissue microarray of hereditary breast cancer not attributable to BRCA1 or BRCA2 mutations: differences from breast carcinomas arising in BRCA1 and BRCA2 mutation carriers.Semantic proximity Read ↗

The molecular pathology of hereditary breast cancer: genetic testing and therapeutic implications.Semantic proximity Read ↗

BRCA2 mutation-associated breast cancers exhibit a distinguishing phenotype based on morphology and molecular profiles from tissue microarrays.Semantic proximity Read ↗

Phenotypic analysis of familial breast cancer: comparison of BRCAx tumors with BRCA1-, BRCA2-carriers and non-familial breast cancer.Semantic proximity Read ↗

The molecular pathology of hereditary breast cancer.Semantic proximity Read ↗

Old and new concepts in histopathological characterization of familial breast cancer.Semantic proximity Read ↗

Pathologic features and immunophenotype of estrogen receptor-positive breast cancers in BRCA1 mutation carriers.Semantic proximity Read ↗

Histopathology of BRCA1- and BRCA2-associated breast cancer.Semantic proximity Read ↗

Histopathological features of breast tumours in BRCA1, BRCA2 and mutation-negative breast cancer families.Semantic proximity Read ↗

Comprehensive Proteomic Profiling-derived Immunohistochemistry-based Prediction Models for BRCA1 and BRCA2 Germline Mutation-related Breast Carcinomas.Semantic proximity Read ↗

Tumor characteristics and prognosis in familial breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.