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Article

Inflammasome Activation by Adenylate Cyclase Toxin Directs Th17 Responses and Protection against <i>Bordetella pertussis</i>

8 Jul 2010

Abstract excerpt

Inflammasome-mediated IL-1beta production is central to the innate immune defects that give rise to certain autoinflammatory diseases and may also be associated with the generation of IL-17-producing CD4(+) T (Th17) cells that mediate autoimmunity. However, the role of the inflammasome in driving adaptive immunity to infection has not been addressed. In this article, we demonstrate that inflammasome-mediated...

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PMID: 20610650
DOI: 10.4049/jimmunol.1000105

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