Article
Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome.
Gastroenterology - 1 Aug 2010
Ng Jeffrey, Hirota Simon A, Gross Olaf, Li Yan, Ulke-Lemee Annegret, Potentier Mireille S, Schenck L Patrick, Vilaysane Akosua, Seamone Mark E, Feng Hanping, Armstrong Glen D, Tschopp Jurg, Macdonald Justin A, Muruve Daniel A, Beck Paul L
Abstract excerpt
BACKGROUND & AIMS: Clostridium difficile-associated disease (CDAD) is the leading cause of nosocomial diarrhea in the United States. C difficile toxins TcdA and TcdB breach the intestinal barrier and trigger mucosal inflammation and intestinal damage. The inflammasome is an intracellular danger sensor of the innate immune system. In the present study, we hypothesize that TcdA and TcdB trigger...
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