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Article

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome.

Nature - 11 Sept 2014

Xu Hao, Yang Jieling, Gao Wenqing, Li Lin, Li Peng, Zhang Li, Gong Yi-Nan, Peng Xiaolan, Xi Jianzhong Jeff, Chen She, Wang Fengchao, Shao Feng

Abstract excerpt

Cytosolic inflammasome complexes mediated by a pattern recognition receptor (PRR) defend against pathogen infection by activating caspase 1. Pyrin, a candidate PRR, can bind to the inflammasome adaptor ASC to form a caspase 1-activating complex. Mutations in the Pyrin-encoding gene, MEFV, cause a human autoinflammatory disease known as familial Mediterranean fever. Despite important roles in immunity and disease,...

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Share to Bacterial Toxins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clostridioides difficile

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Source

Identifiers

PMID: 24919149
DOI: 10.1038/nature13449

Genes

MEFV
RHOA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome.PMID 24919149Read ↗

The immunological function of familial Mediterranean fever disease protein PyrinSemantic proximity Read ↗

Clostridium difficile Toxin B activates the NLRP3 inflammasome in human macrophages, demonstrating a novel regulatory mechanism for the Pyrin inflammasomeSemantic proximity Read ↗

The pyrin inflammasome and the Yersinia effector interaction.Semantic proximity Read ↗

A Burkholderia Type VI Effector Deamidates Rho GTPases to Activate the Pyrin Inflammasome and Trigger InflammationSemantic proximity Read ↗

Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever.Semantic proximity Read ↗

RIPK3 Promotes Mefv Expression and Pyrin Inflammasome Activation via Modulation of mTOR Signaling.Semantic proximity Read ↗

Mutations in the B30.2 and the central helical scaffold domains of pyrin differentially affect inflammasome activation.Semantic proximity Read ↗

Familial Mediterranean fever mutations are hypermorphic mutations that specifically decrease the activation threshold of the Pyrin inflammasome.Semantic proximity Read ↗

The <i>Yersinia pestis</i> effector YopM binds the human pyrin death domain to inhibit inflammasome activation and effector-triggered immunitySemantic proximity Read ↗

Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS.Semantic proximity Read ↗

Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation.Semantic proximity Read ↗

Mutations in the B30.2 and the Central Helical scaffold domains of pyrin differentially affect inflammasome activationSemantic proximity Read ↗

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