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Article

Escherichia coli heat-labile enterotoxin promotes protective Th17 responses against infection by driving innate IL-1 and IL-23 production.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 2011

Brereton Corinna F, Sutton Caroline E, Ross Pádraig J, Iwakura Yoichiro, Pizza Mariagrazia, Rappuoli Rino, Lavelle Ed C, Mills Kingston H G

Abstract excerpt

Escherichia coli heat-labile enterotoxin (LT) is a powerful mucosal adjuvant; however, it is associated with toxic effects when delivered intranasally, and its mechanism of action is poorly understood. In this article, we demonstrate that LT acts as a highly effective adjuvant when administered parenterally, promoting Ag-specific IL-17, as well as IFN-γ, IL-4, and IL-10 production in response to coadministered...

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PMID: 21490151
DOI: 10.4049/jimmunol.1003789

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NLRP3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Escherichia coli heat-labile enterotoxin promotes protective Th17 responses against infection by driving innate IL-1 and IL-23 production.PMID 21490151Read ↗

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