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Article

Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival.

Nature communications - 24 Jul 2017

Buscher Konrad, Ehinger Erik, Gupta Pritha, Pramod Akula Bala, Wolf Dennis, Tweet George, Pan Calvin, Mills Charles D, Lusis Aldons J, Ley Klaus

Abstract excerpt

Although mouse models exist for many immune-based diseases, the clinical translation remains challenging. Most basic and translational studies utilize only a single inbred mouse strain. However, basal and diseased immune states in humans show vast inter-individual variability. Here, focusing on macrophage responses to lipopolysaccharide (LPS), we use the hybrid mouse diversity panel (HMDP) of 83 inbred strains as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28737175
DOI: 10.1038/ncomms16041
PMCID: PMC5527282

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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