Article
Identification of novel susceptibility genes in ozone-induced inflammation in mice.
The European respiratory journal - 1 Aug 2010
Bauer A K, Travis E L, Malhotra S S, Rondini E A, Walker C, Cho H-Y, Trivedi S, Gladwell W, Reddy S, Kleeberger S R
Abstract excerpt
Ozone (O(3)) remains a prevalent air pollutant and public health concern. Inf2 is a significant quantitative trait locus on murine chromosome 17 that contributes to susceptibility to O(3)-induced infiltration of polymorphonuclear leukocytes (PMNs) into the lung, but the mechanisms of susceptibility remain unclear. The study objectives were to confirm and restrict Inf2, and to identify and test novel candidate...
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