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Article

Genomic alterations and allelic imbalances are strong prognostic predictors in osteosarcoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2010

Smida Jan, Baumhoer Daniel, Rosemann Michael, Walch Axel, Bielack Stefan, Poremba Christopher, Remberger Klaus, Korsching Eberhard, Scheurlen Wolfram, Dierkes Christian, Burdach Stefan, Jundt Gernot, Atkinson Michael J, Nathrath Michaela

Abstract excerpt

PURPOSE: Osteosarcoma, the most common primary malignant tumor of the bone, is characterized by complex karyotypes with numerous structural and numerical alterations. Despite attempts to establish molecular prognostic markers at the time of diagnosis, the most accepted predictive factor remains the histologic evaluation of necrosis after neoadjuvant chemotherapy. The present approach was carried out to search for...

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Share to Allelic Imbalance
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20610556
DOI: 10.1158/1078-0432.CCR-10-0284

Genes

CDK4
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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