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Identification of osteosarcoma driver genes by integrative analysis of copy number and gene expression data

27 Mar 2012

Abstract excerpt

High-grade osteosarcoma is a tumor with a complex genomic profile, occurring primarily in adolescents with a second peak at middle age. The extensive genomic alterations obscure the identification of genes driving tumorigenesis during osteosarcoma development. To identify such driver genes, we integrated DNA copy number profiles (Affymetrix SNP 6.0) of 32 diagnostic biopsies with 84 expression profiles (Illumina...

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PMID: 22454324
DOI: 10.1002/gcc.21956

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