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Clinical Genomic Sequencing of Pediatric and Adult Osteosarcoma Reveals Distinct Molecular Subsets with Potentially Targetable Alterations

7 Jun 2019

Abstract excerpt

Abstract Purpose: Although multimodal chemotherapy has improved outcomes for patients with osteosarcoma, the prognosis for patients who present with metastatic and/or recurrent disease remains poor. In this study, we sought to define how often clinical genomic sequencing of osteosarcoma samples could identify potentially actionable alterations. Experimental Design: We analyzed genomic data from 71 osteosarcoma...

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PMID: 31175097
DOI: 10.1158/1078-0432.ccr-18-4032

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