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Article

Genetic imbalances revealed by comparative genomic hybridization in osteosarcomas

7 Oct 2002

Abstract excerpt

Osteosarcomas are the most frequent bone sarcomas. The molecular chromosomal aberrations in osteosarcomas were analyzed by comparative genomic hybridization (CGH). We studied 47 frozen tumors (41 primary samples, 6 relapses) in osteosarcoma patients registered in the Cooperative Osteosarcoma Study (COSS) protocol. Genomic imbalances were detected in 40 of 41 primary tumors and 6 of 6 relapsed tumors. Gains were...

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PMID: 12402305
DOI: 10.1002/ijc.10709

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