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Article

Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma.

PloS one - 1 Jan 2012

Kresse Stine H, Rydbeck Halfdan, Skårn Magne, Namløs Heidi M, Barragan-Polania Ana H, Cleton-Jansen Anne-Marie, Serra Massimo, Liestøl Knut, Hogendoorn Pancras C W, Hovig Eivind, Myklebost Ola, Meza-Zepeda Leonardo A

Abstract excerpt

BACKGROUND: Osteosarcomas are the most common non-haematological primary malignant tumours of bone, and all conventional osteosarcomas are high-grade tumours showing complex genomic aberrations. We have integrated genome-wide genetic and epigenetic profiles from the EuroBoNeT panel of 19 human osteosarcoma cell lines based on microarray technologies. PRINCIPAL FINDINGS: The cell lines showed complex patterns of...

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Share to Bone Neoplasms
Share to DNA Copy Number Variations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Gene Dosage

Share to Genes, Neoplasm

Share to Oligonucleotide Array Sequence Analysis

Share to Osteosarcoma

Source

Open in PubMed Open full text

Identifiers

PMID: 23144859
DOI: 10.1371/journal.pone.0048262
PMCID: PMC3492335

Genes

CXCL5
AKAP12
DLX5
EFEMP1
RUNX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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