Article
Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk.
Carcinogenesis - 1 Oct 2010
Liu Yanhong, Shete Sanjay, Wang Li-E, El-Zein Randa, Etzel Carol J, Liang Fu-Wen, Armstrong Georgina, Tsavachidis Spyros, Gilbert Mark R, Aldape Kenneth D, Xing Jinliang, Wu Xifeng, Wei Qingyi, Bondy Melissa L
Abstract excerpt
BACKGROUND: DNA strand breaks pose the greatest threat to genomic stability. Genetically determined mutagen sensitivity predisposes individuals to a variety of cancers, including glioma. However, polymorphisms in DNA strand break repair genes that may determine mutagen sensitivity are not well studied in cancer risk, especially in gliomas. METHODS: We correlated genotype data for tag single-nucleotide...
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