Article
Comprehensive analysis of the role of DNA repair gene polymorphisms on risk of glioma.
Human molecular genetics - 15 Mar 2008
Bethke Lara, Webb Emily, Murray Anne, Schoemaker Minouk, Johansen Christoffer, Christensen Helle Collatz, Muir Kenneth, McKinney Patricia, Hepworth Sarah, Dimitropoulou Polyxeni, Lophatananon Artitaya, Feychting Maria, Lönn Stefan, Ahlbom Anders, Malmer Beatrice, Henriksson Roger, Auvinen Anssi, Kiuru Anne, Salminen Tiina, Swerdlow Anthony, Houlston Richard
Abstract excerpt
Much of the variation in inherited risk of glioma is likely to be explained by combinations of common low risk variants. The established relationship between glioma risk and exposure to ionizing radiation led us to examine whether variants in the DNA repair genes contribute to disease susceptibility. We evaluated 1127 haplotype-tagging single-nucleotide polymorphisms (SNPs) supplemented with 388 putative...
Topics
- Brain Neoplasms
- Case-Control Studies
- DNA Repair
- Genetic Predisposition to Disease
- Glioma
- Humans
- Polymorphism, Single Nucleotide