Tagging SNPs in non-homologous end-joining pathway genes and risk of glioma.

doi:10.1093/carcin/bgm073

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Article

Tagging SNPs in non-homologous end-joining pathway genes and risk of glioma.

Carcinogenesis - 1 Sept 2007

Liu Yanhong, Zhang Haishi, Zhou Keke, Chen Lina, Xu Zhonghui, Zhong Yu, Liu Hongliang, Li Rui, Shugart Yin Yao, Wei Qingyi, Jin Li, Huang Fengping, Lu Daru, Zhou Liangfu

Abstract excerpt

Ionizing radiation is known to cause DNA damage, including single-strand and double-strand DNA breaks (DSBs), and the unrepair of DNA damage, particularly DSBs, may cause chromosome aberrations. Although the etiology of gliomas remains unclear, exposure to ionizing radiation has been identified as the only established risk factor. We hypothesized that polymorphisms of candidate genes involved in the DSBs repair...

Topics

Brain Neoplasms
Central Nervous System Neoplasms
Chromosome Mapping
DNA Damage
DNA Helicases
DNA Repair
Genotype
Glioma
Humans
Phosphatidylinositol 3-Kinases
Polymorphism, Single Nucleotide
Risk Factors

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Identifiers

PMID: 17389609
DOI: 10.1093/carcin/bgm073

Genes

XRCC5
XRCC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.