Article
Association of core-binding factor β with the malignant phenotype of prostate and ovarian cancer cells.
Journal of cellular physiology - 1 Nov 2010
Davis J Nathan, Rogers Donna, Adams Lisa, Yong Thomas, Jung Jette S, Cheng Bing, Fennell Katie, Borazanci Erkut, Moustafa Yara W, Sun Amanda, Shi Runhua, Glass Jonathan, Mathis J Michael, Williams B Jill, Meyers Shari
Abstract excerpt
Core binding factor (CBF) is a transcription factor complex that plays roles in development, stem-cell homeostasis, and human disease. CBF is a heterodimer composed of one of three DNA-binding RUNX proteins plus the non-DNA-binding protein, CBFβ. Recent studies have showed that the RUNX factors exhibit complex expression patterns in prostate, breast, and ovarian cancers, and CBF has been implicated in the control...
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