Article
A role for CBFβ in maintaining the metastatic phenotype of breast cancer cells.
Oncogene - 1 Mar 2020
Ran Ran, Harrison Hannah, Syamimi Ariffin Nur, Ayub Rahna, Pegg Henry J, Deng Wensheng, Mastro Andrea, Ottewell Penny D, Mason Susan M, Blyth Karen, Holen Ingunn, Shore Paul
Abstract excerpt
Epithelial to mesenchymal transition (EMT) is a dynamic process that drives cancer cell plasticity and is thought to play a major role in metastasis. Here we show, using MDA-MB-231 cells as a model, that the plasticity of at least some metastatic breast cancer cells is dependent on the transcriptional co-regulator CBFβ. We demonstrate that CBFβ is essential to maintain the mesenchymal phenotype of triple-negative...
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