Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Runx transcriptional co-activator, CBFβ, is essential for invasion of breast cancer cells

30 Jun 2010

Abstract excerpt

BACKGROUND: The transcription factor Runx2 has an established role in cancers that metastasize to bone. In metastatic breast cancer cells Runx2 is overexpressed and contributes to the invasive capacity of the cells by regulating the expression of several invasion genes. CBFbeta is a transcriptional co-activator that is recruited to promoters by Runx transcription factors and there is considerable evidence that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Dental Protein Studies
Share to Bone Metabolism and Diseases
Share to Signaling Pathways in Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20591170
DOI: 10.1186/1476-4598-9-171

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Runx transcriptional co-activator, CBFβ, is essential for invasion of breast cancer cellsPMID 20591170Read ↗

Cancer-Associated Exosomal CBFB Facilitates the Aggressive Phenotype, Evasion of Oxidative Stress, and Preferential Predisposition to Bone Prometastatic Factor of Breast Cancer Progression.Semantic proximity Read ↗

A role for CBFβ in maintaining the metastatic phenotype of breast cancer cells.Semantic proximity Read ↗

Regulation of breast cancer metastasis by Runx2 and estrogen signaling: the role of SNAI2Semantic proximity Read ↗

Runx Genes in Breast Cancer and the Mammary Lineage.Semantic proximity Read ↗

The RUNX/CBFβ Complex in Breast Cancer: A Conundrum of Context.Semantic proximity Read ↗

A role for Runx2 in normal mammary gland and breast cancer bone metastasisSemantic proximity Read ↗

Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis <i>in vivo</i>Semantic proximity Read ↗

Targeting of Runx2 by miR-135 and miR-203 Impairs Progression of Breast Cancer and Metastatic Bone DiseaseSemantic proximity Read ↗

Comprehensive Analysis of RUNX and TGF-β Mediated Regulation of Immune Cell Infiltration in Breast CancerSemantic proximity Read ↗

Role of Runx2 in breast cancer-mediated bone metastasisSemantic proximity Read ↗

FOXF2 reprograms breast cancer cells into bone metastasis seedsSemantic proximity Read ↗

The RUNX family in breast cancer: relationships with estrogen signalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.