Article
Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers.
EBioMedicine - 1 Jun 2016
Illendula Anuradha, Gilmour Jane, Grembecka Jolanta, Tirumala Venkata Sesha Srimath, Boulton Adam, Kuntimaddi Aravinda, Schmidt Charles, Wang Lixin, Pulikkan John A, Zong Hongliang, Parlak Mahmut, Kuscu Cem, Pickin Anna, Zhou Yunpeng, Gao Yan, Mishra Lauren, Adli Mazhar, Castilla Lucio H, Rajewski Roger A, Janes Kevin A, Guzman Monica L, Bonifer Constanze, Bushweller John H
Abstract excerpt
Transcription factors have traditionally been viewed with skepticism as viable drug targets, but they offer the potential for completely novel mechanisms of action that could more effectively address the stem cell like properties, such as self-renewal and chemo-resistance, that lead to the failure of traditional chemotherapy approaches. Core binding factor is a heterodimeric transcription factor comprised of one...
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