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Article

Enhanced operator binding by trp superrepressors of Escherichia coli.

The Journal of biological chemistry - 15 May 1990

Hurlburt B K, Yanofsky C

Abstract excerpt

The trp repressor of Escherichia coli binds to the operators of three operons concerned with tryptophan biosynthesis and regulates their expression. trp superrepressors can repress expression of the trp operon in vivo at lower tryptophan concentrations than those required by the wild-type repressor. The five known superrepressors have been purified and characterized using a modified filter binding assay. In four...

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PMID: 1970820

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Enhanced operator binding by trp superrepressors of Escherichia coli.PMID 1970820Read ↗

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The basis for the super-repressor phenotypes of the AV77 and EK18 mutants of trp repressor.Semantic proximity Read ↗

Studies of the Escherichia coli Trp repressor binding to its five operators and to variant operator sequences.Semantic proximity Read ↗

Surface plasmon resonance studies of wild-type and AV77 tryptophan repressor resolve ambiguities in super-repressor activity.Semantic proximity Read ↗

Mutant tryptophan aporepressors with altered specificities of corepressor recognition.Semantic proximity Read ↗

Effect of amino acid alterations in the tryptophan-binding site of the trp repressor.Semantic proximity Read ↗

A negative electrostatic determinant mediates the association between the Escherichia coli trp repressor and its operator DNA.Semantic proximity Read ↗

Isolation of lambda repressor mutants with defects in cooperative operator binding.Semantic proximity Read ↗

Shared operator recognition specificity between Trp repressor and the repressors of bacteriophage 434.Semantic proximity Read ↗

The three-dimensional structure of trp repressor.Semantic proximity Read ↗

The stereochemistry and biochemistry of the trp repressor-operator complex.Semantic proximity Read ↗

The non-inducible nature of super-repressors of the gal operon in Escherichia coli.Semantic proximity Read ↗

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