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Article

11q21.1-11q23.3 Is a site of intrinsic genomic instability triggered by irradiation.

Genes, chromosomes & cancer - 1 Sept 2010

Du Nga, Baker Pamela M, Do To Uyen, Bien Christine, Bier-Laning Carol M, Singh Sheetal, Shih Shyh-Jen, Diaz Manual O, Vaughan Andrew T

Abstract excerpt

The chromosome location, 11q21-23, is linked to loss of heterozygosity (LOH) in multiple tumors including those of breast, lung, and head and neck. To examine the process of LOH induction, the H292 cell line (human muco-epidermoid carcinoma) was irradiated or treated with anti-CD95 antibody, and individual clones isolated through two rounds of cloning. Regions of LOH were determined by screening a suite of eight...

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Share to Carcinoma, Squamous Cell
Share to Chromosomes, Human, Pair 11

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genomic Instability

Share to In Situ Hybridization, Fluorescence

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Source

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Identifiers

PMID: 20607707
DOI: 10.1002/gcc.20791
PMCID: PMC2921793

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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