Article
Deletion of 11q23 is a frequent event in the evolution of MYCN single-copy high-risk neuroblastomas.
Medical and pediatric oncology - 1 Dec 2000
Guo C, White P S, Hogarty M D, Brodeur G M, Gerbing R, Stram D O, Maris J M
Abstract excerpt
BACKGROUND: Deletions of the long arm of chromosome 11 are frequently identified in human neuroblastomas. PROCEDURE: We screened 394 primary neuroblastomas and 52 tumor-derived cell lines with a panel of 11q and 11p polymorphic markers to determine the frequency of chromosome 11 allelic deletion, and to differentiate partial deletions of chromosome 11q (unb[11q] LOH) from whole chromosome loss. RESULTS: Allelic...
Topics
- Alleles
- Child
- Child, Preschool
- Chromosome Deletion
- Chromosomes, Human, Pair 11
- Genes, myc
- Humans
- Infant
- Neuroblastoma
- Risk Factors
- Tumor Cells, Cultured