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Article

The effect of genetic variants in SERPING1 on the risk of neovascular age-related macular degeneration.

The British journal of ophthalmology - 1 Jul 2010

Lee A Y, Kulkarni M, Fang A M, Edelstein S, Osborn M P, Brantley M A

Abstract excerpt

PURPOSE: Genetic factors influence an individual's risk for developing age-related macular degeneration (AMD), a leading cause of irreversible vision loss. Previous studies investigating the potential association between all AMD subtypes and the SERPING1 gene, which encodes a key regulator of the classic complement pathway, have yielded conflicting results. The purpose of this study is to determine whether...

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Share to Complement C1 Inactivator Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 20606025
DOI: 10.1136/bjo.2009.172007
PMCID: PMC3655725

Genes

SERPING1
CFH
HTRA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The effect of genetic variants in SERPING1 on the risk of neovascular age-related macular degeneration.PMID 20606025Read ↗

Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study.Semantic proximity Read ↗

An association study of SERPING1 gene and age-related macular degeneration in a Han Chinese population.Semantic proximity Read ↗

Relationship between SERPING1 rs2511989 polymorphism and age-related macular degeneration risk: a meta-analysis.Semantic proximity Read ↗

Ethnic differences in the association of SERPING1 with age-related macular degeneration and polypoidal choroidal vasculopathy.Semantic proximity Read ↗

Association between the SERPING1 gene and age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese.Semantic proximity Read ↗

Determination of a gene and environment risk model for age-related macular degeneration.Semantic proximity Read ↗

Common variation in the SERPING1 gene is not associated with age-related macular degeneration in two independent groups of subjects.Semantic proximity Read ↗

SERPING1 polymorphisms in polypoidal choroidal vasculopathy.Semantic proximity Read ↗

The Effect of Genetic Variants Associated With Age-Related Macular Degeneration Varies With Age.Semantic proximity Read ↗

Variation in complement component C1 inhibitor in age-related macular degeneration.Semantic proximity Read ↗

Alleles in the HtrA serine peptidase 1 gene alter the risk of neovascular age-related macular degeneration.Semantic proximity Read ↗

Distribution of risk alleles in patients with age-related macular degeneration.Semantic proximity Read ↗

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