Article
Association between the SERPING1 gene and age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese.
PloS one - 19 Apr 2011
Nakata Isao, Yamashiro Kenji, Yamada Ryo, Gotoh Norimoto, Nakanishi Hideo, Hayashi Hisako, Tsujikawa Akitaka, Otani Atsushi, Saito Masaaki, Iida Tomohiro, Oishi Akio, Matsuo Keitaro, Tajima Kazuo, Matsuda Fumihiko, Yoshimura Nagahisa
Abstract excerpt
PURPOSE: Recently, a complement component 1 inhibitor (SERPING1) gene polymorphism was identified as a novel risk factor for age-related macular degeneration (AMD) in Caucasians. We aimed to investigate whether variations in SERPING1 are associated with typical AMD or with polypoidal choroidal vasculopathy (PCV) in a Japanese population. METHODS: We performed a case-control study in a group of Japanese patients...
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