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Article

Alleles in the HtrA serine peptidase 1 gene alter the risk of neovascular age-related macular degeneration.

Ophthalmology - 1 Jul 2008

Deangelis Margaret M, Ji Fei, Adams Scott, Morrison Margaux A, Harring Amanda J, Sweeney Meredith O, Capone Antonio, Miller Joan W, Dryja Thaddeus P, Ott Jurg, Kim Ivana K

Abstract excerpt

OBJECTIVE: To examine if the genes encoding the pleckstrin homology domain-containing protein gene (PLEKHA1), hypothetical LOC387715/ARMS2 gene, and HtrA serine peptidase 1 gene (HTRA1) located on the long arm of chromosome 10 (10q26 region) confer risk for neovascular age-related macular degeneration (AMD) in an independent or interactive manner when controlling for complement factor H gene (CFH) genotype and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18164066
DOI: 10.1016/j.ophtha.2007.10.032
PMCID: PMC4242506

Genes

CFH
HTRA1
ARMS2
PLEKHA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Alleles in the HtrA serine peptidase 1 gene alter the risk of neovascular age-related macular degeneration.PMID 18164066Read ↗

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The NEI/NCBI dbGAP database: genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration.Semantic proximity Read ↗

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Chromosome 10q26 locus and age-related macular degeneration: a progress update.Semantic proximity Read ↗

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A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration.Semantic proximity Read ↗

Specific correlation between the major chromosome 10q26 haplotype conferring risk for age-related macular degeneration and the expression of HTRA1.Semantic proximity Read ↗

Comprehensive analysis of complement factor H and LOC387715/ARMS2/HTRA1 variants with respect to phenotype in advanced age-related macular degeneration.Semantic proximity Read ↗

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