Article
Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site.
Molecular cell - 9 Jul 2010
Roberts-Galbraith Rachel H, Ohi Melanie D, Ballif Bryan A, Chen Jun-Song, McLeod Ian, McDonald W Hayes, Gygi Steven P, Yates John R, Gould Kathleen L
Abstract excerpt
Cytokinesis in Schizosaccharomyces pombe requires the function of Cdc15, the founding member of the pombe cdc15 homology (PCH) family of proteins. As an early, abundant contractile ring component with multiple binding partners, Cdc15 plays a key role in organizing the ring. We demonstrate that Cdc15 phosphorylation at many sites generates a closed conformation, inhibits Cdc15 assembly at the division site in...
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