Article
The S. pombe cdc15 gene is a key element in the reorganization of F-actin at mitosis.
Cell - 11 Aug 1995
Fankhauser C, Reymond A, Cerutti L, Utzig S, Hofmann K, Simanis V
Abstract excerpt
The S. pombe cdc15 gene is essential for cell division. cdc15ts mutants do not form a septum, but growth and nuclear division continue, leading to formation of multinucleate cells. The earliest step in septum formation and cytokinesis, rearrangement of actin to the center of the cell, is associated with appearance of hypophosphorylated cdc15p and formation of a cdc15p ring, which colocalizes with actin. Loss of...
Topics
- Actins
- Amino Acid Sequence
- Cell Cycle Proteins
- Chromosome Mapping
- GTP-Binding Proteins
- Mitosis
- Molecular Sequence Data
- Mutation
- Schizosaccharomyces
- Sequence Alignment