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Article

Pombe Cdc15 homology proteins: regulators of membrane dynamics and the actin cytoskeleton.

Trends in biochemical sciences - 1 Dec 2006

Aspenström Pontus, Fransson Asa, Richnau Ninna

Abstract excerpt

Pombe Cdc15 homology (PCH) proteins have emerged in many species as important coordinators of signalling pathways that regulate actomyosin assembly and membrane dynamics. For example, the prototype PCH protein, Cdc15p of Schizosaccharomyces pombe, has a role in assembly of the contractile ring, which is needed to separate dividing cells. Recently, mammalian PCH proteins have been found to bind phospholipids and...

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Identifiers

PMID: 17074490
DOI: 10.1016/j.tibs.2006.10.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pombe Cdc15 homology proteins: regulators of membrane dynamics and the actin cytoskeleton.PMID 17074490Read ↗

The Cdc15 and Imp2 SH3 domains cooperatively scaffold a network of proteins that redundantly ensure efficient cell division in fission yeast.Semantic proximity Read ↗

Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site.Semantic proximity Read ↗

The F-BAR Cdc15 promotes contractile ring formation through the direct recruitment of the formin Cdc12.Semantic proximity Read ↗

The S. pombe cdc15 gene is a key element in the reorganization of F-actin at mitosis.Semantic proximity Read ↗

Cell cycle-dependent roles for the FCH-domain protein Cdc15p in formation of the actomyosin ring in Schizosaccharomyces pombe.Semantic proximity Read ↗

Schizosaccharomyces pombe cdc4+ gene encodes a novel EF-hand protein essential for cytokinesis.Semantic proximity Read ↗

Curved EFC/F-BAR-domain dimers are joined end to end into a filament for membrane invagination in endocytosis.Semantic proximity Read ↗

Schizosaccharomyces pombe Pxl1 is a paxillin homologue that modulates Rho1 activity and participates in cytokinesis.Semantic proximity Read ↗

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