Article
The Cdc15 and Imp2 SH3 domains cooperatively scaffold a network of proteins that redundantly ensure efficient cell division in fission yeast.
Molecular biology of the cell - 15 Jan 2015
Ren Liping, Willet Alaina H, Roberts-Galbraith Rachel H, McDonald Nathan A, Feoktistova Anna, Chen Jun-Song, Huang Haiming, Guillen Rodrigo, Boone Charles, Sidhu Sachdev S, Beckley Janel R, Gould Kathleen L
Abstract excerpt
Schizosaccharomyces pombe cdc15 homology (PCH) family members participate in numerous biological processes, including cytokinesis, typically by bridging the plasma membrane via their F-BAR domains to the actin cytoskeleton. Two SH3 domain-containing PCH family members, Cdc15 and Imp2, play critical roles in S. pombe cytokinesis. Although both proteins localize to the contractile ring, with Cdc15 preceding Imp2,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.