Article
The F-BAR Cdc15 promotes contractile ring formation through the direct recruitment of the formin Cdc12.
The Journal of cell biology - 16 Feb 2015
Willet Alaina H, McDonald Nathan A, Bohnert K Adam, Baird Michelle A, Allen John R, Davidson Michael W, Gould Kathleen L
Abstract excerpt
In Schizosaccharomyces pombe, cytokinesis requires the assembly and constriction of an actomyosin-based contractile ring (CR). Nucleation of F-actin for the CR requires a single formin, Cdc12, that localizes to the cell middle at mitotic onset. Although genetic requirements for formin Cdc12 recruitment have been determined, the molecular mechanisms dictating its targeting to the medial cortex during cytokinesis...
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