Article
Genetic and molecular characterization of Skb15, a highly conserved inhibitor of the fission yeast PAK, Shk1.
Molecular cell - 1 May 2001
Kim H W, Yang P, Qyang Y, Lai H, Du H, Henkel J S, Kumar K, Bao S, Liu M, Marcus S
Abstract excerpt
The p21-activated kinase, Shk1, is essential for viability, establishment and maintenance of cell polarity, and proper mating response in the fission yeast, Schizosaccharomyces pombe. Here we describe the characterization of a highly conserved, WD repeat protein, Skb15, which negatively regulates Shk1 in fission yeast. A null mutation in the skb15 gene is lethal and results in deregulation of actin polymerization...
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