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Article

Mutation in fission yeast phosphatidylinositol 4-kinase Pik1 is synthetically lethal with defect in telomere protection protein Pot1.

Biochemical and biophysical research communications - 19 Feb 2018

Sugihara Asami, Nguyen Luan Cao, Shamim Hossain Mohammad, Iida Tetsushi, Nakase Mai, Takegawa Kaoru, Senda Mitsuhisa, Jida Shohei, Ueno Masaru

Abstract excerpt

Fission yeast Pik1p is one of three phosphatidylinositol 4-kinases associated with the Golgi complex, but its function is not fully understood. Deletion of pot1+ causes telomere degradation and chromosome circularization. We searched for the gene which becomes synthetically lethal with pot1Δ. We obtained a novel pik1 mutant, pik1-1, which is synthetically lethal with pot1Δ. We found phosphoinositol 4-phosphate in...

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PMID: 29410177
DOI: 10.1016/j.bbrc.2018.02.001

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Mutation in fission yeast phosphatidylinositol 4-kinase Pik1 is synthetically lethal with defect in telomere protection protein Pot1.PMID 29410177Read ↗

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