Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial-nuclear epistasis: implications for human aging and longevity.

Ageing research reviews - 1 Apr 2011

Tranah Gregory J

Abstract excerpt

There is substantial evidence that mitochondria are involved in the aging process. Mitochondrial function requires the coordinated expression of hundreds of nuclear genes and a few dozen mitochondrial genes, many of which have been associated with either extended or shortened life span. Impaired mitochondrial function resulting from mtDNA and nuclear DNA variation is likely to contribute to an imbalance in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Cell Nucleus
Share to Epistasis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Mitochondrial

Share to Longevity

Share to Mitochondria

Share to Oxidative Phosphorylation

Share to Oxidative Stress

Source

Open in PubMed Open full text

Identifiers

PMID: 20601194
DOI: 10.1016/j.arr.2010.06.003
PMCID: PMC2995012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial-nuclear epistasis: implications for human aging and longevity.PMID 20601194Read ↗

Nuclear-mitochondrial epistasis and drosophila aging: introgression of Drosophila simulans mtDNA modifies longevity in D. melanogaster nuclear backgrounds.Semantic proximity Read ↗

Mitochondrial DNA involvement in human longevity.Semantic proximity Read ↗

The emergence of the mitochondrial genome as a partial regulator of nuclear function is providing new insights into the genetic mechanisms underlying age-related complex disease.Semantic proximity Read ↗

Variation in mitochondrial genotype has substantial lifespan effects which may be modulated by nuclear background.Semantic proximity Read ↗

G×G×E for lifespan in Drosophila: mitochondrial, nuclear, and dietary interactions that modify longevity.Semantic proximity Read ↗

Drosophila simulans as a novel model for studying mitochondrial metabolism and aging.Semantic proximity Read ↗

Mitochondria, maternal inheritance, and asymmetric fitness: why males die younger.Semantic proximity Read ↗

Mito-Nuclear Interactions Affecting Lifespan and Neurodegeneration in a Drosophila Model of Leigh Syndrome.Semantic proximity Read ↗

Mitochondria, maternal inheritance, and male aging.Semantic proximity Read ↗

mtDNA mutations in human aging and longevity: controversies and new perspectives opened by high-throughput technologies.Semantic proximity Read ↗

Sirt4 Modulates Oxidative Metabolism and Sensitivity to Rapamycin Through Species-Dependent Phenotypes in Drosophila mtDNA Haplotypes.Semantic proximity Read ↗

Evolutionary perspectives on the links between mitochondrial genotype and disease phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.