Drosophila simulans as a novel model for studying mitochondrial metabolism and aging.

doi:10.1016/j.exger.2005.07.014

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Article

Drosophila simulans as a novel model for studying mitochondrial metabolism and aging.

Experimental gerontology - 1 Oct 2005

Ballard J William O

Abstract excerpt

Mitochondria generate much of the cellular energy through the process of oxidative phosphorylation (OXPHOS). OXPHOS function may be affected by a mutation in any of the mitochondrial (mt) DNA encoded genes and/or nuclear encoded genes that produce proteins imported into the mitochondrion that form (or assemble) the five complexes located on the inner mitochondrial membrane. Decreasing mitochondrial OXPHOS...

Topics

Aging
Animals
DNA, Mitochondrial
Drosophila
Energy Metabolism
Female
Genetic Variation
Longevity
Male
Mitochondria
Models, Biological
Phenotype
Reactive Oxygen Species

Source

Open in PubMed

Identifiers

PMID: 16169180
DOI: 10.1016/j.exger.2005.07.014

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