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Article

Sirt4 Modulates Oxidative Metabolism and Sensitivity to Rapamycin Through Species-Dependent Phenotypes in Drosophila mtDNA Haplotypes.

G3 (Bethesda, Md.) - 4 May 2020

Sejour Richard, Sanguino Roger A, Mikolajczak Monika, Ahmadi Walishah, Villa-Cuesta Eugenia

Abstract excerpt

The endosymbiotic theory proposes that eukaryotes evolved from the symbiotic relationship between anaerobic (host) and aerobic prokaryotes. Through iterative genetic transfers, the mitochondrial and nuclear genomes coevolved, establishing the mitochondria as the hub of oxidative metabolism. To study this coevolution, we disrupt mitochondrial-nuclear epistatic interactions by using strains that have mitochondrial...

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Identifiers

PMID: 32152006
DOI: 10.1534/g3.120.401174
PMCID: PMC7202034

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