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Article

Mito-Nuclear Interactions Affecting Lifespan and Neurodegeneration in a Drosophila Model of Leigh Syndrome.

Genetics - 1 Apr 2018

Loewen Carin A, Ganetzky Barry

Abstract excerpt

Proper mitochondrial activity depends upon proteins encoded by genes in the nuclear and mitochondrial genomes that must interact functionally and physically in a precisely coordinated manner. Consequently, mito-nuclear allelic interactions are thought to be of crucial importance on an evolutionary scale, as well as for manifestation of essential biological phenotypes, including those directly relevant to human...

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PMID: 29496745
DOI: 10.1534/genetics.118.300818
PMCID: PMC5887147

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