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The -351A/G polymorphism of ESR1 is associated with risk of myocardial infarction but not with extreme longevity.

Clinica chimica acta; international journal of clinical chemistry - 14 Dec 2010

Roszkowska-Gancarz Malgorzata, Kurylowicz Alina, Polosak Jacek, Ambroziak Michal, Puzianowska-Kuznicka Monika

Abstract excerpt

BACKGROUND: Women live longer than men. Some possible reasons for this advantage are the protection provided by high concentrations of 17β-estradiol (E2) during the premenopausal period and polymorphic variants of the estrogen receptors (ERs), which mediate various cardiovascular functions of E2. METHODS: We tested whether the -351A/G and -397T/C polymorphisms of the ERα-encoding ESR1 were associated with extreme...

Topics

Adolescent
Adult
Aged, 80 and over
Case-Control Studies
Estrogen Receptor alpha
Female
Genetic Predisposition to Disease
Humans
Longevity
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myocardial Infarction

Polymorphism, Single Nucleotide

Young Adult

Source

Identifiers

PMID: 20599431
DOI: 10.1016/j.cca.2010.06.028

Genes

ESR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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The -351A/G polymorphism of ESR1 is associated with risk of myocardial infarction but not with extreme longevity.PMID 20599431Read ↗

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