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ESR1 genetic variants, haplotypes and the risk of coronary heart disease and ischemic stroke in the Finnish population: a prospective follow-up study.

Atherosclerosis - 1 Jul 2010

Kunnas Tarja, Silander Kaisa, Karvanen Juha, Valkeapää Maria, Salomaa Veikko, Nikkari Seppo

Abstract excerpt

Association of estrogen receptor 1 (ESR1) gene variants and risk of coronary heart disease (CHD) and ischemic stroke was evaluated in the FINRISK-study. From 14,140 individuals, 2225 were selected for genotyping using a case-cohort design. Time-to-event analysis showed that the CC genotype of -397T/C ERS1 gene contributed to higher risk of CHD only in men (HR, 1.68, CI 1.03-2.74). The -351A/G polymorphism was not...

Topics

Adult
Aged
Coronary Disease
Estrogen Receptor alpha
Female
Finland
Haplotypes
Humans
Longitudinal Studies
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Risk

Stroke

Source

Identifiers

PMID: 20153472
DOI: 10.1016/j.atherosclerosis.2010.01.026

Genes

ESR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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