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Article

Post-genomic update on a classical candidate gene for coronary artery disease: ESR1.

Circulation. Cardiovascular genetics - 1 Dec 2011

Lucas Gavin, Lluís-Ganella Carla, Subirana Isaac, Sentí Mariano, Willenborg Christina, Musameh Muntaser D, Schwartz Stephen M, O'Donnell Christopher J, Melander Olle, Salomaa Veikko, Elosua Roberto

Abstract excerpt

BACKGROUND: After age, sex is the most important risk factor for coronary artery disease (CAD). The mechanism through which women are protected from CAD is still largely unknown, but the observed sex difference suggests the involvement of the reproductive steroid hormone signaling system. Genetic association studies of the gene-encoding Estrogen Receptor α (ESR1) have shown conflicting results, although only a...

Topics

Adult
Aged
Coronary Artery Disease
Estrogen Receptor alpha
Female
Genome-Wide Association Study
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 21984528
DOI: 10.1161/CIRCGENETICS.111.960583
PMCID: PMC3260440

Genes

CAD
ESR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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