Article
Homer-1 polymorphisms are associated with psychopathology and response to treatment in schizophrenic patients.
Journal of psychiatric research - 1 Feb 2011
Spellmann Ilja, Rujescu Dan, Musil Richard, Mayr Andreas, Giegling Ina, Genius Just, Zill Peter, Dehning Sandra, Opgen-Rhein Markus, Cerovecki Anja, Hartmann Annette M, Schäfer Martin, Bondy Brigitta, Müller Norbert, Möller Hans-Jürgen, Riedel Michael
Abstract excerpt
The HOMER 1 protein plays a crucial role in mediating glutamatergic neurotransmission. It has previously shown to be a candidate gene for etiology and pathophysiology of different psychiatric diseases such as schizophrenia. To identify genes involved in response to antipsychotics, subgroups of animals were treated with haloperidol (1 mg/kg, n = 11) or saline (n = 12) for one week. By analyzing microarray data, we...
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