Article
RGS4 polymorphisms predict clinical manifestations and responses to risperidone treatment in patients with schizophrenia.
Journal of clinical psychopharmacology - 1 Feb 2008
Lane Hsien-Yuan, Liu Yi-Ching, Huang Chieh-Liang, Chang Yue-Cune, Wu Po-Lun, Huang Chiung-Hsien, Tsai Guochuan E
Abstract excerpt
OBJECTIVE: Polymorphisms of the gene encoding the regulator of G-protein signaling subtype 4 (RGS4) are associated with schizophrenia. This study aims to investigate the association of 4 RGS4 polymorphisms (single nucleotide polymorphisms [SNPs] 1, 4, 7, and 18), implicated in previous studies, with baseline symptoms and treatment response to risperidone in patients with schizophrenia. METHODS: One hundred twenty...
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