LRP-1 polymorphism is associated with global and regional amyloid load in Alzheimer's Disease in humans in-vivo.

doi:10.1016/j.nicl.2014.01.016

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

LRP-1 polymorphism is associated with global and regional amyloid load in Alzheimer's Disease in humans in-vivo.

NeuroImage. Clinical - 1 Jan 2014

Grimmer Timo, Goldhardt Oliver, Guo Liang-Hao, Yousefi Behrooz H, Förster Stefan, Drzezga Alexander, Sorg Christian, Alexopoulos Panagiotis, Förstl Hans, Kurz Alexander, Perneczky Robert

Abstract excerpt

OBJECTIVE: Impaired amyloid clearance has been proposed to contribute to β-amyloid deposition in sporadic late-onset Alzheimer's disease (AD). Low density lipoprotein receptor-related protein 1 (LRP-1) is involved in the active outward transport of β-amyloid across the blood-brain barrier (BBB). The C667T polymorphism (rs1799986) of the LRP-1 gene has been inconsistently associated with AD in genetic studies. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloidogenic Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aniline Compounds

Share to Benzothiazoles

Share to Low Density Lipoprotein Receptor-Related Protein-1

Share to Positron-Emission Tomography

Share to Radiopharmaceuticals

Share to Thiazoles

Share to Tissue Distribution

Source

Open in PubMed Open full text

Identifiers

PMID: 24596678
DOI: 10.1016/j.nicl.2014.01.016
PMCID: PMC3939495

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LRP-1 polymorphism is associated with global and regional amyloid load in Alzheimer's Disease in humans in-vivo.PMID 24596678Read ↗

Progression of cerebral amyloid load is associated with the apolipoprotein E ε4 genotype in Alzheimer's disease.Semantic proximity Read ↗

Variation in the LRP-associated protein gene (LRPAP1) is associated with late-onset Alzheimer disease.Semantic proximity Read ↗

Association between LRP1 C766T polymorphism and Alzheimer's disease susceptibility: a meta-analysis.Semantic proximity Read ↗

Topographical APOE ɛ4 Genotype Influence on Cerebral Metabolism in the Continuum of Alzheimer's Disease: Amyloid Burden Adjusted Analysis.Semantic proximity Read ↗

Influence of ApoE on LRP1 function and amyloid transport across the blood-brain barrierSemantic proximity Read ↗

A LRPAP1 intronic insertion/deletion polymorphism and phenotypic variability in Alzheimer disease.Semantic proximity Read ↗

Association study and meta-analysis of low-density lipoprotein receptor related protein in Alzheimer's disease.Semantic proximity Read ↗

Alzheimer's disease: genetic basis and amyloid imaging as endophenotype.Semantic proximity Read ↗

Regional European differences in allele and genotype frequencies of low density lipoprotein receptor-related protein 1 polymorphism in Alzheimer's disease.Semantic proximity Read ↗

Modulation of amyloid β-protein clearance and Alzheimer’s disease susceptibility by the LDL receptor–related protein pathwaySemantic proximity Read ↗

Differential effect of APOE genotype on amyloid load and glucose metabolism in AD dementia.Semantic proximity Read ↗

A 3'-UTR polymorphism in the oxidized LDL receptor 1 gene increases Abeta40 load as cerebral amyloid angiopathy in Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.