Article
A versatile gene-based test for genome-wide association studies.
American journal of human genetics - 9 Jul 2010
Liu Jimmy Z, McRae Allan F, Nyholt Dale R, Medland Sarah E, Wray Naomi R, Brown Kevin M, Hayward Nicholas K, Montgomery Grant W, Visscher Peter M, Martin Nicholas G, Macgregor Stuart
Abstract excerpt
We have derived a versatile gene-based test for genome-wide association studies (GWAS). Our approach, called VEGAS (versatile gene-based association study), is applicable to all GWAS designs, including family-based GWAS, meta-analyses of GWAS on the basis of summary data, and DNA-pooling-based GWAS, where existing approaches based on permutation are not possible, as well as singleton data, where they are. The...
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