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Article

The generalized odds ratio as a measure of genetic risk effect in the analysis and meta-analysis of association studies.

Statistical applications in genetics and molecular biology - 1 Jan 2010

Zintzaras Elias

Abstract excerpt

The significance of risk effects in genetic association studies is assessed using the odds ratio for various genetic models (dominant, recessive and co-dominant) by merging genotypes. These models are not independent and there is no a priori biological justification for their choice. Consequently, the interpretation of their results can be problematic, especially when multiallelic variants and disease progression...

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PMID: 20597847
DOI: 10.2202/1544-6115.1542

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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